Hemojuvelin regulates the innate immune response to peritoneal bacterial infection in mice

Irradiated β-glucan enhances immune response to bacterial infection through CD4 and CD8 T-lymphocytes

Background: &beta-glucans are glucose polymers with a variety of stimulatory effects on the immune system. The objective of this study was to evaluate the immune-enhancing activities of low molecular weight gamma irradiated &beta-glucan (I&beta-g) extracted from Pleurotus ostreatus in response to Pseudomonas aeruginosa infection in rats. Materials and Methods: &beta-glucan (&beta-g) powder was ...

Innate Immune Responses in Mice The Tumor Suppressor ARF Regulates

The Innate Immune Response to Vaccinia Viral Infection

The Innate Immune Response to Vaccinia Viral Infection by Jennifer Martinez Department of Immunology Duke University Date:_______________________ Approved: ___________________________ Yiping Yang, MD, Ph.D, Supervisor ___________________________ Weiguo Zhang, Ph.D, Chair ___________________________ Motonari Kondo, MD, Ph.D ___________________________ Michael Krangel, Ph.D ______________________...

Modeling Innate Immune Response to Early Mycobacterium Infection

In the study of complex patterns in biology, mathematical and computational models are emerging as important tools. In addition to experimental approaches, these modeling tools have recently been applied to address open questions regarding host-pathogen interaction dynamics, including the immune response to mycobacterial infection and tuberculous granuloma formation. We present an approach in w...

Human lung innate immune response to Bacillus anthracis spore infection.

Bacillus anthracis, the causative agent of inhalational anthrax, enters a host through the pulmonary system before dissemination. We have previously shown that human alveolar macrophages participate in the initial innate immune response to B. anthracis spores through cell signal-mediated cytokine release. We proposed that the lung epithelia also participate in the innate immune response to this...